diff --git a/packages/mui-material/src/Select/Select.test.js b/packages/mui-material/src/Select/Select.test.js
index 4599548c848d92..c3818ad13c4d93 100644
--- a/packages/mui-material/src/Select/Select.test.js
+++ b/packages/mui-material/src/Select/Select.test.js
@@ -33,6 +33,54 @@ describe('<Select />', () => {
     skip: ['componentProp', 'componentsProp', 'themeVariants', 'themeStyleOverrides'],
   }));
 
+  describe('WCAG 2.5.2 - Pointer Cancellation', () => {
+    it('should close the menu when dragging away and releasing', () => {
+      const { getByRole, queryByRole } = render(
+        <Select value="">
+          <MenuItem value="">none</MenuItem>
+          <MenuItem value={10}>Ten</MenuItem>
+        </Select>,
+      );
+      const trigger = getByRole('combobox');
+
+      // Open the menu with left mouse button
+      fireEvent.mouseDown(trigger, { button: 0 });
+      expect(getByRole('listbox')).not.to.equal(null);
+
+      // Simulate mouse move to initiate drag
+      fireEvent.mouseMove(document.body);
+
+      // Simulate mouse up outside any menu items
+      fireEvent.mouseUp(document.body);
+
+      // Menu should be closed now
+      expect(queryByRole('listbox', { hidden: false })).to.equal(null);
+    });
+
+    it('should not close the menu when releasing on a menu item after dragging', () => {
+      const { getByRole, getAllByRole } = render(
+        <Select value="">
+          <MenuItem value="">none</MenuItem>
+          <MenuItem value={10}>Ten</MenuItem>
+        </Select>,
+      );
+      const trigger = getByRole('combobox');
+
+      // Open the menu
+      fireEvent.mouseDown(trigger, { button: 0 });
+      const options = getAllByRole('option');
+
+      // Simulate mouse move to initiate drag
+      fireEvent.mouseMove(document.body);
+
+      // Simulate mouse up on a menu item
+      fireEvent.mouseUp(options[0]);
+
+      // Menu should still be open
+      expect(getByRole('listbox')).not.to.equal(null);
+    });
+  });
+
   describe('prop: inputProps', () => {
     it('should be able to provide a custom classes property', () => {
       render(
diff --git a/packages/mui-material/src/Select/SelectInput.js b/packages/mui-material/src/Select/SelectInput.js
index 58255517fe8eac..7fe7f28933eb86 100644
--- a/packages/mui-material/src/Select/SelectInput.js
+++ b/packages/mui-material/src/Select/SelectInput.js
@@ -162,6 +162,11 @@ const SelectInput = React.forwardRef(function SelectInput(props, ref) {
 
   const anchorElement = displayNode?.parentNode;
 
+  const [isPointerDown, setIsPointerDown] = React.useState(false);
+  const dragSelectRef = React.useRef({
+    isDragging: false,
+  });
+
   React.useImperativeHandle(
     handleRef,
     () => ({
@@ -210,20 +215,23 @@ const SelectInput = React.forwardRef(function SelectInput(props, ref) {
     return undefined;
   }, [labelId]);
 
-  const update = (open, event) => {
-    if (open) {
-      if (onOpen) {
-        onOpen(event);
+  const update = React.useCallback(
+    (open, event) => {
+      if (open) {
+        if (onOpen) {
+          onOpen(event);
+        }
+      } else if (onClose) {
+        onClose(event);
       }
-    } else if (onClose) {
-      onClose(event);
-    }
 
-    if (!isOpenControlled) {
-      setMenuMinWidthState(autoWidth ? null : anchorElement.clientWidth);
-      setOpenState(open);
-    }
-  };
+      if (!isOpenControlled) {
+        setMenuMinWidthState(autoWidth ? null : anchorElement.clientWidth);
+        setOpenState(open);
+      }
+    },
+    [autoWidth, anchorElement, isOpenControlled, onOpen, onClose, setOpenState],
+  );
 
   const handleMouseDown = (event) => {
     // Ignore everything but left-click
@@ -234,6 +242,10 @@ const SelectInput = React.forwardRef(function SelectInput(props, ref) {
     event.preventDefault();
     displayRef.current.focus();
 
+    // Mark that we've initiated a pointer interaction
+    setIsPointerDown(true);
+
+    // Open the menu immediately
     update(true, event);
   };
 
@@ -258,6 +270,56 @@ const SelectInput = React.forwardRef(function SelectInput(props, ref) {
     }
   };
 
+  React.useEffect(() => {
+    if (isPointerDown) {
+      const doc = ownerDocument(displayRef.current);
+
+      const handleGlobalMouseUp = (event) => {
+        setIsPointerDown(false);
+
+        if (dragSelectRef.current.isDragging) {
+          // If we're dragging and the mouse is released, check where it was released
+          dragSelectRef.current.isDragging = false;
+
+          // Check if mouse is over a menu item
+          const targetElement = event.target;
+          let menuItem = null;
+
+          // Find if we released on a menu item (checking up the parent chain)
+          let current = targetElement;
+          while (current && !menuItem) {
+            // Check if this element has role="option"
+            if (current.getAttribute && current.getAttribute('role') === 'option') {
+              menuItem = current;
+            }
+            current = current.parentElement;
+          }
+
+          if (!menuItem) {
+            // If released outside menu items, close the menu
+            update(false, event);
+          }
+        }
+      };
+
+      const handleGlobalMouseMove = () => {
+        if (isPointerDown) {
+          dragSelectRef.current.isDragging = true;
+        }
+      };
+
+      doc.addEventListener('mouseup', handleGlobalMouseUp);
+      doc.addEventListener('mousemove', handleGlobalMouseMove);
+
+      return () => {
+        doc.removeEventListener('mouseup', handleGlobalMouseUp);
+        doc.removeEventListener('mousemove', handleGlobalMouseMove);
+      };
+    }
+
+    return undefined;
+  }, [isPointerDown, update]);
+
   const handleItemClick = (child) => (event) => {
     let newValue;